Ectopia lentis, Isolated AD

Clinical Characteristics
Ocular Features: 

Ectopia lentis as an isolated finding has been known for many years although early reports did not rule out features of the Marfan syndrome (154700).  In more recent reports clinical evidence of the Marfan syndrome has been absent in a number of families and there seems little doubt that mutations in the FBN1 can be responsible for isolated ectopia lentis.  Iridodenesis may be noted at birth but the dislocated lens may not be diagnosed until late adulthood in mild cases.  Vision can be normal but nystagmus and strabismus have been noted in other patients. The lenses may be dislocated superiorly and may contain opacities.  Areas of missing zonules have been observed in some patients while others have posterior synechiae.

Systemic Features: 

Related family members have been observed to have polydactyly and craniosynostosis but without dislocated lenses.  It is important to rule out skeletal and cardiac manifestations of the Marfan syndrome because of the prognostic implications.

Genetics

This is an autosomal dominant disorder attributed to mutations in FBN1 (15q21), the same gene that is mutant in the Marfan syndrome (154700).  The dislocated lenses may represent variable expressivity or simply allelism.  The latter seems more likely in view of the fact that numerous thoroughly studied individuals have not had the skeletal or cardiovascular signs of the Marfan syndrome (154700).  However, the revised Ghent nosology now suggests that all patients with the FBN1 mutation and ectopia lentis be designated to have the Marfan syndrome when aortic dilation/dissection is present as well.  This should be extended to include all patients with FBN1 mutations and ectopia lentis plus at least one other phenotypic feature of the Marfan syndrome.

The same gene is mutant in the autosomal dominant form of the Weill-Marchesani 2 syndrome (608328) which is allelic to the Marfan syndrome. 

There is also an autosomal recessive condition of isolated ectopia lentis (225100) which results from homozygous nonsense mutations in ADAMTSL4 (225100). A patient with craniosynostosis and ectopia lentis has been reported in which there was a homozygous 20 bp deletion in the same gene.

Treatment
Treatment Options: 

Lens removal may be indicated when vision cannot otherwise be corrected.

References
Article Title: 

The Revised Ghent Nosology; Reclassifying Isolated Ectopia Lentis

Chandra A, Patel D, Aragon-Martin JA, Pinard A, Collod-Beroud G, Comeglio P, Boileau C, Faivre L, Charteris D, Child AH, Arno G. The Revised Ghent Nosology; Reclassifying Isolated Ectopia Lentis. Clin Genet. 2014 Feb 7. [Epub ahead of print].

PubMed ID: 
24635535

Pathogenic FBN1 mutations in 146 adults not meeting clinical diagnostic criteria for Marfan syndrome: further delineation of type 1 fibrillinopathies and focus on patients with an isolated major criterion

Faivre L, Collod-Beroud G, Callewaert B, Child A, Loeys BL, Binquet C, Gautier E, Arbustini E, Mayer K, Arslan-Kirchner M, Kiotsekoglou A, Comeglio P, Grasso M, Beroud C, Bonithon-Kopp C, Claustres M, Stheneur C, Bouchot O, Wolf JE, Robinson PN, Ades L, De Backer J, Coucke P, Francke U, De Paepe A, Boileau C, Jondeau G. Pathogenic FBN1 mutations in 146 adults not meeting clinical diagnostic criteria for Marfan syndrome: further delineation of type 1 fibrillinopathies and focus on patients with an isolated major criterion. Am J Med Genet A. 2009 May;149A(5):854-60.

PubMed ID: 
19353630

Ectopia lentis phenotypes and the FBN1 gene

Ades LC, Holman KJ, Brett MS, Edwards MJ, Bennetts B. Ectopia lentis phenotypes and the FBN1 gene. Am J Med Genet A. 2004 Apr 30;126A(3):284-9. Review.

PubMed ID: 
15054843

References

Chandra A, Patel D, Aragon-Martin JA, Pinard A, Collod-Beroud G, Comeglio P, Boileau C, Faivre L, Charteris D, Child AH, Arno G. The Revised Ghent Nosology; Reclassifying Isolated Ectopia Lentis. Clin Genet. 2014 Feb 7. [Epub ahead of print].

PubMedID: 24635535

Zhao JH, Jin TB, Liu QB, Chen C, Hu HT. Ophthalmic findings in a family with early-onset isolated ectopia lentis and the p.Arg62Cys mutation of the fibrillin-1 gene (FBN1). Ophthalmic Genet. 2012 Sep 6. [Epub ahead of print].

PubMedID: 22950452

Chandra A, Aragon-Martin JA, Sharif S, Parulekar M, Child A, Arno G. Craniosynostosis with Ectopia Lentis and a Homozygous 20-base Deletion in ADAMTSL4. Ophthalmic Genet. 2012 Aug 7. [Epub ahead of print].

PubMedID: 22871183

Faivre L, Collod-Beroud G, Callewaert B, Child A, Loeys BL, Binquet C, Gautier E, Arbustini E, Mayer K, Arslan-Kirchner M, Kiotsekoglou A, Comeglio P, Grasso M, Beroud C, Bonithon-Kopp C, Claustres M, Stheneur C, Bouchot O, Wolf JE, Robinson PN, Ades L, De Backer J, Coucke P, Francke U, De Paepe A, Boileau C, Jondeau G. Pathogenic FBN1 mutations in 146 adults not meeting clinical diagnostic criteria for Marfan syndrome: further delineation of type 1 fibrillinopathies and focus on patients with an isolated major criterion. Am J Med Genet A. 2009 May;149A(5):854-60.

PubMedID: 19353630

Ades LC, Holman KJ, Brett MS, Edwards MJ, Bennetts B. Ectopia lentis phenotypes and the FBN1 gene. Am J Med Genet A. 2004 Apr 30;126A(3):284-9. Review.

PubMedID: 15054843

Edwards MJ, Challinor CJ, Colley PW, Roberts J, Partington MW, Hollway GE, Kozman HM, Mulley JC. Clinical and linkage study of a large family with simple ectopia lentis linked to FBN1. Am J Med Genet. 1994 Oct 15;53(1):65-71.

PubMedID: 7802039