Stocker-Holt dystrophy is clinically somewhat similar to Meesmann corneal dystrophy but is caused by a different mutation and is therefore discussed separately here. Stocker and Holt in 1954 described this disorder among 20 descendents from Moravia who settled in North Carolina (Meesmann and Wilke's report in 1939 was based on patients in Germany). Fine, grayish punctate epithelial opacities were found in the epithelium anterior to Bowman's throughout the entire cornea even in patients as young as 7 months old. These stain with fluorescein and are accompanied by fine linear opacities that appear in a whorled pattern. Outside of light sensitivity and glare reported by some patients, few are symptomatic. Spontaneous, recurrent epithelial erosions can occur. Corneal sensitivity is reduced. Contact lenses are poorly tolerated. Visual acuity is generally around 20/50 but can be significantly worse. Few require keratoplasty.
Meesmann dystrophy (122100) is superficially similar but the opacities are more numerous in the interpalpebral area and the surrounding epithelium is generally clear.