corneal erosion

Blatt Distichiasis

Clinical Characteristics
Ocular Features: 

Distichiasis, or two rows of eyelashes, is sometimes confused with districhiasis (three rows of lashes) or trichiasis.  True distichiasis often occurs in all four lids and is sometimes associated with other lid anomalies such as ptosis, trichiasis, corneal damage, congenital ectropion and absence of Meibomian glands.  It has occasionally been found only in the lower lids and much more rarely just in the upper lids. In distichiasis, the second row of lashes emerges from the orifices of the Meibomian glands which distinguishes it from acquired trichiasis in which the normally placed lashes are misdirected.  The abnormal lashes are usually thinner, shorter, and less pigmented than the normal lashes.  They number from 3-20 with an average of 12-15.

Systemic Features: 

No consistent systemic associations have been reported.


Pedigrees consistent with autosomal dominant inheritance have been reported but no locus or gene has been identified. 

A Chinese family with affected father and one affected male and female offspring has been reported with distichiasis but no lymphedema.  A premature stop codon was found in the FOXC2 transcription gene (16q24.1) in these family members suggesting that they may have had the lymphedema-distichiasis syndrome (153400) instead. 

In some patients with anhidrotic ectodermal dysplasia (224900) there is also a double row of lashes but these exit anterior to the Meibomian gland orifices.

Distichiasis also occurs as part of the lymphedema-distichiasis syndrome (153400) as well as the blepharocheilodontic syndrome (119580). Aberrant rows of eyelashes have been reported in Setleis syndrome (227260).

Autosomal dominant
Treatment Options: 

Electrolysis of misdirected lashes may be used when individual lashes cause corneal damage.

Article Title: 


Fox SA. Distichiasis. Am J Ophthalmol. 1962 Jan;53:14-8.

PubMed ID: 
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