Corneal Dystrophy, Recurrent Epithelial Erosions Clinical CharacteristicsOcular Features: Individuals have the onset of recurrent corneal erosions as a result of as yet unknown disease processes. Onset is in the first decade of life (even in the first year of life) often with some subepithelial haze or blebs while denser centrally located opacities develop with time. Erosions often are precipitated by relatively minor trauma and are often difficult to treat, lasting for up to a week. Fortunately, the erosions become less frequent as patients age and may cease altogether by the fifth decade of life. Systemic Features: No systemic disease is associated with ERED. GeneticsThe few reported families have all had an autosomal dominant pattern of inheritance. So far no locus or molecular defect has been identified. The clinical features of this condition are found in other corneal dystrophies and it is likely that at least some of the reported cases may have had other unrecognized corneal conditions. Pedigree: Autosomal dominantTreatmentTreatment Options: The usual corneal erosion treatment of hypertonic solutions, bandage patching, and lubricating ointments may be helpful for acute erosions. No long term preventative treatment has been found effective. Corneal transplants remain clear centrally although peripheral opacities may reappear within a few years. ReferencesArticle Title: Franceschetti Hereditary Recurrent Corneal Erosion Lisch W, Bron AJ, Munier FL, Schorderet DF, Tiab L, Lange C, Saikia P, Reinhard T, Weiss JS, Gundlach E, Pleyer U, Lisch C, Auw-Haedrich C. Franceschetti Hereditary Recurrent Corneal Erosion. Am J Ophthalmol. 2012 Mar 7. [Epub ahead of print]. PubMed ID: 22402249 A new corneal disease with recurrent erosive episodes and autosomal-dominant inheritance Hammar B, Bjorck E, Lagerstedt K, Dellby A, Fagerholm P. A new corneal disease with recurrent erosive episodes and autosomal-dominant inheritance. Acta Ophthalmol. 2008 Nov;86(7):758-63. PubMed ID: 18778339 Hereditary recurring corneal erosions. A familial study with special reference to Fuchs' dystrophy Valle O. Hereditary recurring corneal erosions. A familial study with special reference to Fuchs' dystrophy. Acta Ophthalmol (Copenh). 1967;45(6):829-36. PubMed ID: 5300718 A family history of corneal erosions Wales HJ. A family history of corneal erosions. Trans Ophthalmol Soc N Z. 1955;8:77-8. PubMed ID: 13380984 Read more about Corneal Dystrophy, Recurrent Epithelial Erosions
Franceschetti Hereditary Recurrent Corneal Erosion Lisch W, Bron AJ, Munier FL, Schorderet DF, Tiab L, Lange C, Saikia P, Reinhard T, Weiss JS, Gundlach E, Pleyer U, Lisch C, Auw-Haedrich C. Franceschetti Hereditary Recurrent Corneal Erosion. Am J Ophthalmol. 2012 Mar 7. [Epub ahead of print]. PubMed ID: 22402249
A new corneal disease with recurrent erosive episodes and autosomal-dominant inheritance Hammar B, Bjorck E, Lagerstedt K, Dellby A, Fagerholm P. A new corneal disease with recurrent erosive episodes and autosomal-dominant inheritance. Acta Ophthalmol. 2008 Nov;86(7):758-63. PubMed ID: 18778339
Hereditary recurring corneal erosions. A familial study with special reference to Fuchs' dystrophy Valle O. Hereditary recurring corneal erosions. A familial study with special reference to Fuchs' dystrophy. Acta Ophthalmol (Copenh). 1967;45(6):829-36. PubMed ID: 5300718
A family history of corneal erosions Wales HJ. A family history of corneal erosions. Trans Ophthalmol Soc N Z. 1955;8:77-8. PubMed ID: 13380984
