Clinical Characteristics
Ocular Features
A variety of chorioretinal lesions have been described in Aicardi syndrome including lacunae (‘holes’) in 88%, and choroid plexus papillomas which are considered specific and characteristic. These tend to be more common in the posterior pole. They are stable and do not enlarge. They can usually be distinguished from post-infection scars by the absence of pigmentation. A bull's eye maculopathy may be present. Optic nerve colobomas (in 42%) and hypoplasia have been reported. At least 61% of eyes have some optic nerve abnormalities. Presumed microphthalmia has been noted in 25% of patients. A minority of patients have a persistent pupillary membrane. Sparse lateral eyebrows have also been reported with .
There is evidence that the primary molecular defect involves Bruch's membrane resulting in damage to the RPE.
Congenital glaucoma has been diagnosed in several patients.
Systemic Features
Patients with Aicardi syndrome are considered to have a characteristic facial phenotype with a prominent premaxilla, upturned nasal tip, and decreased angle of the nasal bridge. Several patients have been reported with vertebral anomalies as well as cleft lip and palate. The most severe symptoms including infantile spasms, developmental delay, and seizures are the result of a generalized neuronal migration disorder evident on MRI as polymicrogyria, periventricular heterotopia, and various malformations of the corpus callosum. The latter structure is absent in 72% of patients. Intracranial cysts and cerebellar dysplasia have been reported in 95% of patients. MRI of the brain often shows asymmetry and unilateral microphthalmia is often present on the side of the more severe brain lesions. Most individuals have some intellectual disabilities and do not live beyond childhood.
Genetics
Inheritance
Since virtually all reported cases have been female this is considered to be a dominant X-linked disorder with lethality in hemizygous males. The presumed locus is at Xp22 although no specific gene mutation has been identified. Interestingly, several affected XXY (Klinefelter syndrome) males have been reported which is consistent with the most likely mode of inheritance. It has been proposed that the majority of cases results from new mutations since familial cases are exceedingly rare.
Aicard-Goutieres syndromes are separate disorders.
Pedigree
X-linked dominant, father affected
X-linked inheritance patterns result when disease-causing mutations are located on the X chromosome. Males have one X chromosome while females have two. A mutation on the male's X chromosome frequently is lethal or renders him unable to reproduce. However, in rare cases when males have children, they can expect that all of then will inherit the condition.
X-linked inheritance patterns result when disease-causing mutations are located on the X chromosome. Males have one X chromosome while females have two. A mutation on the male's X chromosome frequently is lethal or at least renders them unable to reproduce. However, in rare cases when males have children, they can expect that all of then will inherit the condition.
X-linked dominant, mother affected
X-linked inheritance patterns result from mutations located on the X chromosome. Females have two X chromosomes of which only one carries a mutation in X-linked dominant disorders. This usually results in expression of the disease and women with a single mutation have the disorder caused by the mutation. Half of their offspring, male and female, will inherit the mutation. Men, with only one X chromosome, will always have the condition if they inherit the one with the mutation. Men would transmit it to all of their offspring. Without a modifying normal gene on a second X chromosome, X-linked dominant conditions are frequently lethal in such males. The result is a vertical transmission pattern, usually from female to female.
X-linked inheritance patterns result from mutations located on the X chromosome. Females have two X chromosomes of which only one carries a mutation in X-linked dominant disorders. This usually results in expression of the disease and women with a single mutation have the disorder caused by the mutation. Half of their offspring, male and female, will inherit the mutation. Men, with only one X chromosome, will always have the condition if they inherit the one with the mutation. Men would transmit it to all of their offspring. Without a modifying normal gene on a second X chromosome, X-linked dominant conditions are frequently lethal in such males. The result is a vertical transmission pattern, usually from female to female.