Abdominal pain, vomiting and hypoglycemia usually appears in infancy upon the introduction of fructose or sucrose to the diet. Some infants have a more severe reaction to such sugars with lethargy, seizures and coma. Older children and adults develop a protective aversion to fruits and sweets. Chronic ingestion leads to liver cirrhosis, renal tubule damage, growth retardation, and even malnutrition. Adults may also have hypoglycemia and metabolic acidosis when challenged with sucrose and fructose.