lens opacities

Cataracts, Congenital, Autosomal Dominant

Clinical Characteristics
Ocular Features: 

Most cataracts arise as part of the aging process.  However, early onset lens opacities may be familial, often transmitted in an autosomal dominant pattern.  These have a highly variable appearance and may be unilateral or bilateral.  There can be considerable interocular asymmetry in morphology, density, location, and rate of progression.  This is also true of intrafamilial characteristics.  Age of onset is variable. 

Systemic Features: 

There are no associated systemic abnormalities. 


At least 25 loci scattered among multiple chromosome have been identified to cause simple autosomal dominant cataracts (See 604219).  It is not yet possible to make phenotypic - genotypic correlations due to the large variation in clinical characteristics. 


Autosomal dominant
Treatment Options: 

Lens extraction is indicated when the opacities become visually significant. 

Article Title: 
Subscribe to RSS - lens opacities